AirHint found the following cheapest return flights from Orlando (MCO) to Panama City (PTY) in October 2025 (see full year).

Return flights

29 Oct - 06 Nov	Spirit Airlines
03 Oct - 10 Oct	Spirit Airlines
02 Oct - 05 Oct	Volaris Costa Rica
03 Oct - 06 Oct	Volaris Costa Rica
09 Oct - 13 Oct	Volaris Costa Rica
09 Oct - 12 Oct	Volaris Costa Rica
03 Oct - 05 Oct	Volaris Costa Rica
22 Oct - 05 Nov	Frontier Airlines
02 Oct - 10 Oct	Frontier Airlines
15 Oct - 31 Oct	Spirit Airlines
30 Oct - 05 Nov	Copa	direct
22 Oct - 05 Nov	Copa	direct
29 Oct - 06 Nov	Copa	direct
11 Oct - 13 Oct	Copa	direct
09 Oct - 13 Oct	Copa	direct

Also check the deals for one-way flights from Orlando to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Orlando to Panama City in October from $350

Return flights