AirHint found the following cheapest return flights from Orlando (MCO) to Panama City (PTY) in December 2025 (see full year).

Return flights

30 Dec - 14 Jan	Copa	direct
25 Dec - 27 Dec	Copa	direct
26 Dec - 30 Dec	American Airlines
12 Dec - 07 Jan	American Airlines
31 Dec - 04 Jan	Avianca
27 Dec - 02 Jan	American Airlines
26 Dec - 30 Dec	Copa	direct
28 Dec - 02 Jan	Copa	direct
27 Dec - 02 Jan	Copa	direct
29 Dec - 02 Jan	Copa	direct
12 Dec - 07 Jan	Copa	direct
31 Dec - 04 Jan	Copa	direct

Also check the deals for one-way flights from Orlando to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Orlando to Panama City in December from $439

Return flights