AirHint found the following cheapest return flights from Rio Negro (MDE) to Sao Paulo (GRU) in April 2026 (see full year).

Return flights

23 Apr - 30 Apr	LATAM Airlines Group
17 Apr - 21 Apr	GOL Linhas Aéreas
24 Apr - 30 Apr	GOL Linhas Aéreas
04 Apr - 11 Apr	GOL Linhas Aéreas

Also check the deals for one-way flights from Rio Negro to Sao Paulo in April.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rio Negro to Sao Paulo in April from $415

Return flights