AirHint found the following cheapest return flights from Rio Negro (MDE) to Guayaquil (GYE) in December 2025 (see full year).
Return flights
| 05 Dec - 12 Dec | Avianca | direct | |
| 01 Dec - 02 Jan | Avianca | direct | |
| 15 Dec - 02 Jan | Avianca | direct | |
| 17 Dec - 19 Dec | Avianca | direct | |
| 19 Dec - 21 Dec | LATAM Airlines Group |
Also check the deals for one-way flights from Rio Negro to Guayaquil in December.
The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.
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