Cheapest return flights from Rio Negro to Guayaquil in December from $294

AirHint found the following cheapest return flights from Rio Negro (MDE) to Guayaquil (GYE) in December 2025 (see full year).

Return flights

15 Dec - 20 Dec Copa
17 Dec - 22 Dec Copa
15 Dec - 02 Jan Copa
17 Dec - 24 Dec Copa
19 Dec - 25 Jan Copa
17 Dec - 24 Dec Avianca direct
29 Dec - 01 Jan Avianca
21 Dec - 17 Jan Avianca
14 Dec - 20 Dec Avianca
31 Dec - 05 Jan Avianca direct
18 Dec - 06 Jan Copa
23 Dec - 04 Jan Copa
30 Dec - 04 Jan Avianca
30 Dec - 02 Jan Avianca
19 Dec - 24 Jan Avianca

Also check the deals for one-way flights from Rio Negro to Guayaquil in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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