AirHint found the following cheapest return flights from Rio Negro (MDE) to Guayaquil (GYE) in May 2026 (see full year).
Return flights
| 01 May - 08 May | Copa | ||
| 01 May - 08 May | Avianca | direct | |
| 13 May - 03 Jun | Avianca | direct | |
| 11 May - 01 Jun | Avianca | direct | |
| 25 May - 03 Jun | Avianca | ||
| 24 May - 02 Jun | Copa |
Also check the deals for one-way flights from Rio Negro to Guayaquil in May.
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