AirHint found the following cheapest return flights from Rio Negro (MDE) to Guayaquil (GYE) in September 2025 (see full year).

Return flights

29 Sep - 03 Oct	Avianca
19 Sep - 21 Sep	Avianca
29 Sep - 01 Oct	Avianca
19 Sep - 22 Sep	Avianca
30 Sep - 03 Oct	Avianca
26 Sep - 29 Sep	Avianca	direct
26 Sep - 01 Oct	Avianca	direct
21 Sep - 28 Sep	Avianca
29 Sep - 02 Oct	Avianca
29 Sep - 12 Oct	Avianca
20 Sep - 27 Sep	Avianca
19 Sep - 22 Sep	Avianca	direct
19 Sep - 26 Sep	Avianca
26 Sep - 26 Sep	Avianca
21 Sep - 23 Sep	Avianca
22 Sep - 27 Sep	LATAM Airlines Group

Also check the deals for one-way flights from Rio Negro to Guayaquil in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rio Negro to Guayaquil in September from $326

Return flights