AirHint found the following cheapest return flights from Rio Negro (MDE) to Madrid (MAD) in October 2025 (see full year).

Return flights

01 Oct - 17 Oct	Spirit Airlines
06 Oct - 16 Oct	Spirit Airlines
17 Oct - 26 Oct	Spirit Airlines
03 Oct - 19 Oct	Spirit Airlines
15 Oct - 29 Oct	Copa
07 Oct - 15 Oct	Spirit Airlines
10 Oct - 25 Oct	Avianca
30 Oct - 17 Nov	Avianca
27 Oct - 15 Nov	Avianca
05 Oct - 14 Oct	Avianca
27 Oct - 16 Nov	Avianca
07 Oct - 28 Oct	Avianca
04 Oct - 18 Oct	Spirit Airlines
19 Oct - 07 Nov	Avianca
20 Oct - 04 Nov	JetSmart
21 Oct - 07 Nov	JetSmart
08 Oct - 26 Nov	JetSmart
30 Oct - 18 Nov	JetSmart
27 Oct - 14 Nov	Air Europa	direct
21 Oct - 07 Nov	Air Europa	direct

Also check the deals for one-way flights from Rio Negro to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Madrid

Cheap car rent in Madrid

Cheapest return flights from Rio Negro to Madrid in October from $718

Return flights