AirHint found the following cheapest return flights from Rio Negro (MDE) to Santiago (SCL) in October 2025 (see full year).

Return flights

12 Oct - 27 Oct	JetSmart
21 Oct - 27 Oct	JetSmart
21 Oct - 11 Nov	JetSmart
21 Oct - 10 Nov	JetSmart
06 Oct - 27 Oct	JetSmart
21 Oct - 04 Nov	JetSmart
25 Oct - 27 Oct	JetSmart
21 Oct - 03 Nov	JetSmart
06 Oct - 08 Oct	JetSmart
20 Oct - 27 Oct	JetSmart
25 Oct - 11 Nov	JetSmart
12 Oct - 28 Oct	JetSmart
25 Oct - 10 Nov	JetSmart
25 Oct - 04 Nov	JetSmart
21 Oct - 28 Oct	JetSmart
06 Oct - 09 Oct	JetSmart
26 Oct - 11 Nov	JetSmart
20 Oct - 10 Nov	JetSmart
20 Oct - 04 Nov	JetSmart
12 Oct - 16 Oct	JetSmart

Also check the deals for one-way flights from Rio Negro to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rio Negro to Santiago in October from $281

Return flights