AirHint found the following cheapest return flights from Chicago (MDW) to Istanbul (IST) in November 2025 (see full year).

Return flights

14 Nov - 06 Dec	KLM
13 Nov - 06 Dec	KLM
04 Nov - 07 Nov	Frontier Airlines
12 Nov - 06 Dec	KLM
11 Nov - 21 Nov	Delta
05 Nov - 19 Nov	Delta
28 Nov - 02 Dec	Delta
03 Nov - 10 Nov	Delta
22 Nov - 13 Dec	KLM
01 Nov - 22 Nov	KLM
07 Nov - 29 Nov	Air France
03 Nov - 29 Nov	Air France
03 Nov - 04 Dec	KLM
18 Nov - 13 Dec	KLM
02 Nov - 10 Nov	Delta
20 Nov - 29 Nov	Delta
21 Nov - 13 Dec	KLM

Also check the deals for one-way flights from Chicago to Istanbul in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Chicago to Istanbul in November from $725

Return flights