AirHint found the following cheapest return flights from Chicago (MDW) to Istanbul (IST) in December 2025 (see full year).

Return flights

27 Dec - 14 Jan	Air France
02 Dec - 16 Dec	Delta
03 Dec - 15 Jan	KLM
05 Dec - 27 Dec	KLM
13 Dec - 23 Dec	Air France
13 Dec - 20 Dec	Air France
24 Dec - 01 Jan	Air France
13 Dec - 03 Jan	WestJet
19 Dec - 18 Jan	Delta
27 Dec - 16 Jan	Delta
13 Dec - 22 Dec	KLM
22 Dec - 30 Dec	Delta
17 Dec - 19 Jan	KLM
20 Dec - 07 Jan	Delta
16 Dec - 30 Dec	Delta
18 Dec - 11 Jan	Delta
22 Dec - 12 Jan	KLM

Also check the deals for one-way flights from Chicago to Istanbul in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Chicago to Istanbul in December from $923

Return flights