AirHint found the following cheapest return flights from Chicago (MDW) to Rio Negro (MDE) in December 2025 (see full year).

Return flights

24 Dec - 28 Dec	Frontier Airlines
19 Dec - 23 Dec	Frontier Airlines
15 Dec - 04 Jan	Frontier Airlines
19 Dec - 22 Dec	Frontier Airlines
30 Dec - 06 Jan	Frontier Airlines
31 Dec - 05 Jan	Frontier Airlines
26 Dec - 04 Jan	Frontier Airlines
25 Dec - 05 Jan	Frontier Airlines
16 Dec - 22 Dec	Frontier Airlines
16 Dec - 23 Dec	LATAM Airlines Group
28 Dec - 04 Jan	Frontier Airlines
16 Dec - 20 Dec	LATAM Airlines Group
07 Dec - 10 Dec	LATAM Airlines Group
06 Dec - 09 Dec	LATAM Airlines Group
08 Dec - 12 Dec	LATAM Airlines Group

Also check the deals for one-way flights from Chicago to Rio Negro in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Chicago to Rio Negro in December from $601

Return flights