AirHint found the following cheapest return flights from Chicago (MDW) to Prague (PRG) in December 2025 (see full year).

Return flights

11 Dec - 18 Dec	Delta
28 Dec - 17 Jan	Frontier Airlines
11 Dec - 03 Jan	Frontier Airlines
15 Dec - 21 Dec	Delta
13 Dec - 09 Jan	Delta
17 Dec - 04 Jan	Delta
20 Dec - 01 Jan	Delta
18 Dec - 04 Jan	Delta
28 Dec - 04 Jan	Delta

Also check the deals for one-way flights from Chicago to Prague in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Chicago to Prague in December from $637

Return flights