AirHint found the following cheapest return flights from Chicago (MDW) to Pisa (PSA) in April 2026 (see full year).

Return flights

30 Apr - 08 May	Frontier Airlines
21 Apr - 29 Apr	Frontier Airlines
15 Apr - 23 Apr	Frontier Airlines
14 Apr - 22 Apr	Frontier Airlines
22 Apr - 30 Apr	Frontier Airlines
25 Apr - 03 May	Frontier Airlines
16 Apr - 23 Apr	Frontier Airlines
23 Apr - 30 Apr	Frontier Airlines
29 Apr - 07 May	Frontier Airlines
24 Apr - 01 May	Frontier Airlines
02 Apr - 09 Apr	Air France
26 Apr - 04 May	Frontier Airlines
02 Apr - 10 Apr	Air France
10 Apr - 18 Apr	KLM
03 Apr - 10 Apr	KLM
28 Apr - 06 May	KLM
24 Apr - 02 May	KLM

Also check the deals for one-way flights from Chicago to Pisa in April.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Chicago to Pisa in April from $476

Return flights