AirHint found the following cheapest return flights from Chicago (MDW) to Panama City (PTY) in December 2025 (see full year).
Return flights
| 06 Dec - 10 Dec | Frontier Airlines | ||
| 07 Dec - 10 Dec | Frontier Airlines | ||
| 05 Dec - 10 Dec | Delta | ||
| 17 Dec - 24 Dec | Delta | ||
| 27 Dec - 02 Jan | Frontier Airlines |
Also check the deals for one-way flights from Chicago to Panama City in December.
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