AirHint found the following cheapest return flights from Chicago (MDW) to Quito (UIO) in September 2025 (see full year).

Return flights

24 Sep - 03 Oct	Delta
22 Sep - 18 Oct	LATAM Airlines Group
21 Sep - 15 Oct	Delta
21 Sep - 19 Oct	Frontier Airlines
18 Sep - 28 Sep	LATAM Airlines Group
13 Sep - 16 Sep	LATAM Airlines Group
17 Sep - 20 Sep	LATAM Airlines Group
05 Sep - 12 Sep	LATAM Airlines Group
12 Sep - 14 Sep	LATAM Airlines Group

Also check the deals for one-way flights from Chicago to Quito in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Chicago to Quito in September from $470

Return flights