AirHint found the following cheapest return flights from Mexico City (MEX) to Sao Paulo (GRU) in September 2025 (see full year).

Return flights

14 Sep - 24 Sep	Arajet
17 Sep - 24 Sep	Arajet
04 Sep - 19 Sep	Arajet
03 Sep - 17 Sep	Arajet
18 Sep - 22 Sep	Arajet
14 Sep - 26 Sep	Arajet
28 Sep - 10 Oct	Arajet
22 Sep - 30 Sep	Aeromexico	direct
09 Sep - 18 Sep	Aeromexico	direct
08 Sep - 15 Sep	Aeromexico	direct
16 Sep - 25 Sep	Aeromexico	direct
25 Sep - 02 Oct	Arajet
25 Sep - 03 Oct	Arajet
28 Sep - 10 Oct	LATAM Airlines Group	direct
29 Sep - 06 Oct	Copa
25 Sep - 04 Oct	Arajet

Also check the deals for one-way flights from Mexico City to Sao Paulo in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Sao Paulo in September from $411

Return flights