AirHint found the following cheapest return flights from Mexico City (MEX) to Rio Negro (MDE) in September 2025 (see full year).

Return flights

13 Sep - 19 Sep	Avianca
10 Sep - 18 Sep	Avianca
10 Sep - 24 Sep	Avianca
06 Sep - 11 Sep	Avianca
08 Sep - 15 Sep	Arajet
26 Sep - 03 Oct	Arajet
08 Sep - 12 Sep	Avianca
04 Sep - 11 Sep	Avianca
10 Sep - 18 Sep	Aeromexico	direct
02 Sep - 09 Sep	Aeromexico	direct
21 Sep - 28 Sep	Aeromexico	direct
25 Sep - 03 Oct	Aeromexico	direct
22 Sep - 01 Oct	Copa
17 Sep - 01 Oct	Copa
27 Sep - 04 Oct	Aeromexico	direct

Also check the deals for one-way flights from Mexico City to Rio Negro in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Rio Negro in September from $221

Return flights