AirHint found the following cheapest return flights from Mexico City (MEX) to Panama City (PTY) in November 2025 (see full year).

Return flights

27 Nov - 04 Dec	Avianca
20 Nov - 27 Nov	Avianca
18 Nov - 25 Nov	Aeromexico	direct
23 Nov - 03 Dec	Aeromexico	direct
30 Nov - 19 Dec	Aeromexico	direct
18 Nov - 24 Nov	Avianca
18 Nov - 21 Nov	Avianca
17 Nov - 20 Nov	Avianca
19 Nov - 23 Nov	Avianca
21 Nov - 23 Nov	Avianca
29 Nov - 06 Dec	Avianca
21 Nov - 30 Nov	Avianca
13 Nov - 24 Nov	Avianca
20 Nov - 24 Nov	Avianca
28 Nov - 03 Dec	Avianca
29 Nov - 06 Dec	Copa	direct
27 Nov - 04 Dec	Copa	direct
28 Nov - 02 Dec	Copa	direct
28 Nov - 03 Dec	Copa	direct

Also check the deals for one-way flights from Mexico City to Panama City in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Panama City in November from $301

Return flights