Cheapest return flights from Mexico City to Panama City in December from $446

Best time to book flights for Mexico City (MEX) to Panama City (PTY) flights at AirHint

AirHint found the following cheapest return flights from Mexico City (MEX) to Panama City (PTY) in December 2025 (see full year).

Return flights

27 Dec - 07 Jan Aeromexico direct
01 Dec - 10 Dec Aeromexico direct
01 Dec - 08 Dec Aeromexico direct
08 Dec - 12 Dec Aeromexico direct
22 Dec - 27 Dec Aeromexico direct
12 Dec - 19 Dec Aeromexico direct
04 Dec - 12 Dec Aeromexico direct
27 Dec - 10 Jan Aeromexico direct
24 Dec - 29 Dec Aeromexico direct

Also check the deals for one-way flights from Mexico City to Panama City in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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