AirHint found the following cheapest return flights from Mexico City (MEX) to Panama City (PTY) in December 2025 (see full year).

Return flights

31 Dec - 14 Jan	Copa	direct
31 Dec - 12 Jan	Copa	direct
30 Dec - 13 Jan	Copa	direct
30 Dec - 07 Jan	Copa	direct
31 Dec - 07 Jan	Copa	direct
30 Dec - 09 Jan	Copa
31 Dec - 10 Jan	Avianca
30 Dec - 06 Jan	Copa	direct
31 Dec - 11 Jan	Copa
31 Dec - 10 Jan	Copa	direct
27 Dec - 28 Dec	Avianca
27 Dec - 28 Dec	Aeromexico	direct
28 Dec - 30 Dec	Viva
29 Dec - 30 Dec	Viva
27 Dec - 29 Dec	Viva

Also check the deals for one-way flights from Mexico City to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Panama City in December from $269

Return flights