Cheapest return flights from Mexico City to Panama City in December from $278

AirHint found the following cheapest return flights from Mexico City (MEX) to Panama City (PTY) in December 2025 (see full year).

Return flights

24 Dec - 31 Dec Aeromexico direct
24 Dec - 07 Jan Aeromexico direct
30 Dec - 15 Jan Aeromexico direct
10 Dec - 18 Dec Aeromexico direct
09 Dec - 16 Dec Aeromexico direct
10 Dec - 17 Dec Aeromexico direct
13 Dec - 20 Dec Aeromexico direct
24 Dec - 01 Jan Aeromexico direct
11 Dec - 18 Dec Aeromexico direct
09 Dec - 15 Dec Aeromexico direct
02 Dec - 07 Dec Aeromexico direct
01 Dec - 06 Dec Aeromexico direct
24 Dec - 06 Jan Copa direct
30 Dec - 01 Jan Aeromexico
24 Dec - 04 Jan Aeromexico
30 Dec - 02 Jan Aeromexico
26 Dec - 29 Dec Copa direct
30 Dec - 01 Jan Aeromexico direct
30 Dec - 10 Jan Aeromexico
30 Dec - 10 Jan Aeromexico direct

Also check the deals for one-way flights from Mexico City to Panama City in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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