Cheapest return flights from Mexico City to Panama City in December from $310

AirHint found the following cheapest return flights from Mexico City (MEX) to Panama City (PTY) in December 2025 (see full year).

Return flights

08 Dec - 15 Dec Aeromexico direct
27 Dec - 07 Jan Aeromexico direct
10 Dec - 22 Dec Aeromexico direct
02 Dec - 10 Dec Avianca
02 Dec - 10 Dec Copa direct
22 Dec - 27 Dec Avianca
19 Dec - 29 Dec Avianca
26 Dec - 02 Jan Copa direct
19 Dec - 29 Dec Aeromexico direct
27 Dec - 02 Jan Avianca
28 Dec - 04 Jan Aeromexico direct
27 Dec - 02 Jan Aeromexico direct
22 Dec - 27 Dec Copa direct
20 Dec - 27 Dec Copa direct

Also check the deals for one-way flights from Mexico City to Panama City in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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