Cheapest return flights from Mexico City to Panama City in December from $266

AirHint found the following cheapest return flights from Mexico City (MEX) to Panama City (PTY) in December 2025 (see full year).

Return flights

14 Dec - 25 Dec Aeromexico direct
07 Dec - 24 Dec Aeromexico direct
21 Dec - 31 Dec Aeromexico direct
14 Dec - 24 Dec Aeromexico direct
31 Dec - 14 Jan Aeromexico direct
31 Dec - 07 Jan Aeromexico direct
24 Dec - 31 Dec Aeromexico direct
18 Dec - 25 Dec Aeromexico direct
05 Dec - 08 Dec Avianca
18 Dec - 24 Dec Aeromexico direct
31 Dec - 13 Jan Aeromexico direct
14 Dec - 21 Dec Aeromexico direct
21 Dec - 07 Jan Aeromexico direct
29 Dec - 06 Jan Aeromexico direct
01 Dec - 08 Dec Avianca
28 Dec - 06 Jan Aeromexico direct
12 Dec - 11 Jan Copa direct
15 Dec - 24 Jan Copa direct
30 Dec - 06 Jan Aeromexico direct
30 Dec - 05 Jan Copa

Also check the deals for one-way flights from Mexico City to Panama City in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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