AirHint found the following cheapest return flights from Mexico City (MEX) to Panama City (PTY) in April 2026 (see full year).

Return flights

23 Apr - 07 May	Aeromexico	direct
26 Apr - 03 May	Aeromexico	direct
06 Apr - 13 Apr	Aeromexico	direct
29 Apr - 06 May	Aeromexico	direct
23 Apr - 01 May	Aeromexico	direct
15 Apr - 18 Apr	Avianca
08 Apr - 18 Apr	Avianca
09 Apr - 13 Apr	Avianca
09 Apr - 12 Apr	Avianca
08 Apr - 12 Apr	Avianca
29 Apr - 03 May	Avianca
23 Apr - 27 Apr	Aeromexico	direct
10 Apr - 13 Apr	Aeromexico	direct
15 Apr - 20 Apr	Aeromexico	direct
09 Apr - 13 Apr	Aeromexico	direct
30 Apr - 04 May	Aeromexico	direct
29 Apr - 04 May	Aeromexico	direct
29 Apr - 03 May	Copa	direct

Also check the deals for one-way flights from Mexico City to Panama City in April.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Panama City

Cheap car rent in Panama City

Cheapest return flights from Mexico City to Panama City in April from $316

Return flights