AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in November 2025 (see full year).

Return flights

18 Nov - 28 Nov	LATAM Airlines Group	direct
10 Nov - 14 Nov	Avianca
19 Nov - 01 Dec	Avianca
17 Nov - 28 Nov	Copa
12 Nov - 29 Nov	Copa
18 Nov - 25 Nov	Copa
22 Nov - 29 Nov	Copa
22 Nov - 27 Nov	Copa
19 Nov - 24 Nov	Copa
20 Nov - 23 Nov	Copa
02 Nov - 16 Nov	Copa
25 Nov - 05 Dec	Arajet
24 Nov - 05 Dec	Copa
19 Nov - 09 Dec	Copa
28 Nov - 02 Dec	Copa
21 Nov - 05 Dec	Copa
24 Nov - 05 Dec	Aeromexico	direct
10 Nov - 10 Dec	Aeromexico	direct
27 Nov - 01 Dec	Avianca
21 Nov - 01 Dec	Avianca

Also check the deals for one-way flights from Mexico City to Santiago in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Santiago in November from $516

Return flights