AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in April 2026 (see full year).

Return flights

09 Apr - 19 Apr	Arajet
20 Apr - 29 Apr	Volaris
20 Apr - 27 Apr	Volaris
14 Apr - 19 Apr	Volaris
06 Apr - 15 Apr	Volaris
21 Apr - 26 Apr	Volaris
21 Apr - 25 Apr	Volaris
16 Apr - 25 May	Arajet
19 Apr - 25 Apr	Copa
19 Apr - 24 Apr	Copa
20 Apr - 24 Apr	Copa
24 Apr - 02 May	Copa
24 Apr - 03 May	Copa
30 Apr - 30 May	Copa
15 Apr - 15 May	LATAM Airlines Group
15 Apr - 15 May	LATAM Airlines Group	direct
24 Apr - 02 May	LATAM Airlines Group	direct
15 Apr - 02 May	Viva
15 Apr - 05 May	Viva
25 Apr - 02 May	Viva

Also check the deals for one-way flights from Mexico City to Santiago in April.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Santiago in April from $467

Return flights