AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in April 2026 (see full year).

Return flights

09 Apr - 16 Apr	Arajet
09 Apr - 19 Apr	Arajet
30 Apr - 09 May	Copa
25 Apr - 09 May	Avianca
01 Apr - 15 Apr	LATAM Airlines Group
02 Apr - 16 Apr	LATAM Airlines Group
20 Apr - 27 Apr	Avianca
15 Apr - 18 Apr	Avianca
17 Apr - 22 Apr	Avianca
25 Apr - 09 May	LATAM Airlines Group	direct
04 Apr - 15 Apr	Avianca
01 Apr - 06 Apr	Avianca
01 Apr - 08 Apr	Avianca
23 Apr - 08 May	Viva
22 Apr - 08 May	Viva
17 Apr - 08 May	Viva
20 Apr - 08 May	Viva
23 Apr - 04 May	Viva
15 Apr - 04 May	Viva
14 Apr - 04 May	Viva

Also check the deals for one-way flights from Mexico City to Santiago in April.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Santiago in April from $585

Return flights