Cheapest return flights from Mexico City to Santiago in May from $419

Best time to book flights for Mexico City (MEX) to Santiago (SCL) flights at AirHint

AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in May 2025 (see full year).

Return flights

15 May - 21 May Arajet
18 May - 28 May Arajet
11 May - 14 May Arajet
21 May - 27 May Copa
12 May - 20 May Copa
12 May - 23 May Copa
13 May - 16 May Copa
23 May - 30 May Copa
15 May - 25 May Copa
27 May - 31 May Copa
12 May - 16 Jun Copa
28 May - 11 Jun Copa
27 May - 09 Jun Copa
17 May - 03 Jun Copa
23 May - 15 Jun Copa
27 May - 10 Jun Copa
31 May - 09 Jun Copa
31 May - 06 Jun Copa
26 May - 03 Jun Copa
31 May - 10 Jun Avianca

Also check the deals for one-way flights from Mexico City to Santiago in May.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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