AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in May 2026 (see full year).

Return flights

10 May - 13 May	Arajet
07 May - 13 May	Arajet
03 May - 13 May	Arajet
28 May - 12 Jun	Arajet
23 May - 30 May	Volaris
14 May - 23 May	Volaris
14 May - 19 May	Volaris
21 May - 25 May	Volaris
01 May - 04 May	Volaris
03 May - 09 May	Volaris
25 May - 03 Jun	Volaris
02 May - 10 May	Volaris
21 May - 06 Jun	Arajet
29 May - 21 Jun	Volaris
27 May - 09 Jun	Copa
25 May - 11 Jun	LATAM Airlines Group
29 May - 06 Jun	LATAM Airlines Group
27 May - 03 Jun	Viva
27 May - 04 Jun	Viva
22 May - 03 Jun	Viva

Also check the deals for one-way flights from Mexico City to Santiago in May.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Santiago in May from $422

Return flights