AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in September 2025 (see full year).

Return flights

16 Sep - 22 Sep	Arajet
24 Sep - 27 Sep	Avianca
18 Sep - 24 Sep	Avianca
18 Sep - 29 Sep	Avianca
08 Sep - 18 Sep	Avianca
07 Sep - 17 Sep	Arajet
02 Sep - 09 Sep	Avianca
16 Sep - 30 Sep	LATAM Airlines Group
08 Sep - 19 Sep	Avianca
18 Sep - 26 Sep	Avianca
15 Sep - 06 Oct	Avianca
25 Sep - 10 Oct	Avianca
29 Sep - 03 Oct	Avianca
28 Sep - 03 Oct	Avianca
15 Sep - 06 Oct	LATAM Airlines Group	direct
21 Sep - 12 Oct	LATAM Airlines Group
21 Sep - 11 Oct	LATAM Airlines Group
19 Sep - 17 Oct	LATAM Airlines Group

Also check the deals for one-way flights from Mexico City to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Santiago in September from $424

Return flights