AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in September 2025 (see full year).

Return flights

23 Sep - 06 Oct	Arajet
25 Sep - 01 Oct	Arajet
28 Sep - 03 Oct	Arajet
28 Sep - 02 Oct	Arajet
30 Sep - 08 Oct	Arajet
18 Sep - 24 Sep	Arajet
09 Sep - 25 Sep	Avianca
26 Sep - 06 Oct	Avianca
25 Sep - 29 Sep	Arajet
11 Sep - 18 Sep	Avianca
27 Sep - 06 Oct	Avianca
30 Sep - 10 Oct	Copa
30 Sep - 09 Oct	Copa
23 Sep - 30 Sep	Arajet
26 Sep - 19 Oct	Avianca
05 Sep - 27 Sep	Avianca
09 Sep - 22 Sep	Avianca
05 Sep - 17 Sep	Avianca
11 Sep - 27 Sep	Avianca
11 Sep - 24 Sep	Avianca

Also check the deals for one-way flights from Mexico City to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Santiago in September from $466

Return flights