AirHint found the following cheapest return flights from Miami (MIA) to Santiago (SCL) in September 2025 (see full year).

Return flights

13 Sep - 27 Sep	Sky Airline
12 Sep - 18 Oct	Sky Airline
12 Sep - 27 Sep	Sky Airline
14 Sep - 21 Sep	Sky Airline
01 Sep - 07 Sep	Sky Airline
13 Sep - 29 Sep	Sky Airline
17 Sep - 20 Sep	Sky Airline
16 Sep - 23 Sep	Sky Airline
15 Sep - 22 Sep	Sky Airline
05 Sep - 21 Sep	Sky Airline
03 Sep - 24 Sep	Sky Airline
30 Sep - 14 Oct	Sky Airline
26 Sep - 12 Oct	Sky Airline
29 Sep - 06 Oct	Sky Airline
09 Sep - 01 Oct	Sky Airline
30 Sep - 14 Oct	LATAM Airlines Group	direct
29 Sep - 06 Oct	LATAM Airlines Group	direct
30 Sep - 11 Oct	Copa
12 Sep - 18 Oct	American Airlines	direct

Also check the deals for one-way flights from Miami to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago

Cheapest return flights from Miami to Santiago in September from $423

Return flights