AirHint found the following cheapest return flights from Minneapolis (MSP) to Rome (FCO) in September 2025 (see full year).

Return flights

28 Sep - 03 Oct	Frontier Airlines
29 Sep - 15 Oct	Sun Country Airlines
22 Sep - 02 Oct	Frontier Airlines
27 Sep - 15 Oct	Sun Country Airlines
29 Sep - 16 Oct	Aer Lingus
28 Sep - 14 Oct	Frontier Airlines
25 Sep - 15 Oct	Frontier Airlines
28 Sep - 16 Oct	WestJet
26 Sep - 15 Oct	Frontier Airlines
27 Sep - 16 Oct	Frontier Airlines
07 Sep - 13 Sep	Frontier Airlines
16 Sep - 26 Sep	Frontier Airlines
07 Sep - 13 Sep	Air France	direct

Also check the deals for one-way flights from Minneapolis to Rome in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Minneapolis to Rome in September from $608

Return flights