AirHint found the following cheapest return flights from Chicago (ORD) to Rome (FCO) in September 2025 (see full year).

Return flights

21 Sep - 30 Sep	TAP
06 Sep - 30 Sep	TAP
01 Sep - 08 Sep	TAP
15 Sep - 24 Sep	TAP
08 Sep - 17 Sep	TAP
22 Sep - 02 Oct	TAP
07 Sep - 15 Sep	TAP
20 Sep - 30 Sep	TAP
04 Sep - 14 Sep	TAP
04 Sep - 10 Sep	TAP
04 Sep - 17 Sep	TAP
22 Sep - 03 Oct	TAP
23 Sep - 07 Oct	Spirit Airlines
19 Sep - 01 Oct	TAP
29 Sep - 10 Oct	Scandinavian Airlines
23 Sep - 06 Oct	Air Canada
24 Sep - 06 Oct	Spirit Airlines
25 Sep - 04 Oct	TAP
26 Sep - 06 Oct	Spirit Airlines
20 Sep - 19 Oct	Turkish Airlines

Also check the deals for one-way flights from Chicago to Rome in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Chicago to Rome in September from $374

Return flights