AirHint found the following cheapest return flights from Chicago (ORD) to Sao Paulo (GRU) in December 2025 (see full year).

Return flights

04 Dec - 08 Dec	Copa
04 Dec - 14 Dec	LATAM Airlines Group
03 Dec - 13 Dec	LATAM Airlines Group
06 Dec - 14 Dec	Arajet
15 Dec - 12 Jan	Arajet
15 Dec - 13 Jan	Arajet
15 Dec - 11 Jan	Arajet
12 Dec - 12 Jan	Spirit Airlines
24 Dec - 14 Jan	Copa
16 Dec - 12 Jan	Spirit Airlines
08 Dec - 10 Jan	Spirit Airlines
14 Dec - 13 Jan	Copa
03 Dec - 13 Dec	United	direct
16 Dec - 13 Jan	Spirit Airlines
15 Dec - 01 Jan	Arajet
30 Dec - 31 Dec	LATAM Airlines Group
12 Dec - 14 Dec	Delta
08 Dec - 18 Dec	LATAM Airlines Group
06 Dec - 16 Dec	LATAM Airlines Group
05 Dec - 15 Dec	Spirit Airlines

Also check the deals for one-way flights from Chicago to Sao Paulo in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Sao Paulo

Cheap car rent in Sao Paulo

Cheapest return flights from Chicago to Sao Paulo in December from $475

Return flights