AirHint found the following cheapest return flights from Chicago (ORD) to Sao Paulo (GRU) in April 2026 (see full year).

Return flights

01 Apr - 08 Apr	United	direct
02 Apr - 09 Apr	United	direct
05 Apr - 12 Apr	United	direct
07 Apr - 14 Apr	United	direct
15 Apr - 22 Apr	United	direct
16 Apr - 23 Apr	United	direct
17 Apr - 24 Apr	United	direct
23 Apr - 30 Apr	United	direct
26 Apr - 03 May	United	direct
28 Apr - 05 May	United	direct
29 Apr - 06 May	United	direct
30 Apr - 07 May	United	direct
06 Apr - 13 Apr	Copa
08 Apr - 15 Apr	Copa
27 Apr - 04 May	Copa
24 Apr - 01 May	United	direct
25 Apr - 02 May	United	direct

Also check the deals for one-way flights from Chicago to Sao Paulo in April.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Chicago to Sao Paulo in April from $475

Return flights