AirHint found the following cheapest return flights from Chicago (ORD) to Prague (PRG) in October 2025 (see full year).

Return flights

21 Oct - 29 Oct	Scandinavian Airlines
29 Oct - 08 Nov	Scandinavian Airlines
27 Oct - 03 Nov	Scandinavian Airlines
02 Oct - 30 Oct	Scandinavian Airlines
08 Oct - 17 Oct	Icelandair
31 Oct - 22 Nov	Scandinavian Airlines
29 Oct - 02 Nov	Scandinavian Airlines
10 Oct - 01 Nov	LOT
08 Oct - 01 Nov	LOT
14 Oct - 28 Oct	Air Canada
10 Oct - 18 Oct	LOT
10 Oct - 12 Oct	LOT
10 Oct - 13 Oct	LOT
17 Oct - 21 Oct	LOT
23 Oct - 26 Oct	LOT
05 Oct - 25 Oct	LOT

Also check the deals for one-way flights from Chicago to Prague in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Chicago to Prague in October from $373

Return flights