Cheapest return flights from Chicago to Prague in September from $544

AirHint found the following cheapest return flights from Chicago (ORD) to Prague (PRG) in September 2025 (see full year).

Return flights

25 Sep - 17 Oct Icelandair
30 Sep - 31 Oct United
20 Sep - 11 Oct Air Canada
25 Sep - 16 Oct Frontier Airlines
16 Sep - 02 Oct Condor
25 Sep - 18 Oct SWISS
26 Sep - 26 Oct SWISS
16 Sep - 03 Oct Frontier Airlines
17 Sep - 02 Oct Spirit Airlines
18 Sep - 03 Oct LOT

Also check the deals for one-way flights from Chicago to Prague in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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