AirHint found the following cheapest return flights from Chicago (ORD) to Prague (PRG) in September 2025 (see full year).

Return flights

16 Sep - 28 Sep	Scandinavian Airlines
18 Sep - 28 Sep	Scandinavian Airlines
06 Sep - 14 Sep	Scandinavian Airlines
06 Sep - 10 Sep	Scandinavian Airlines
01 Sep - 14 Sep	Scandinavian Airlines
03 Sep - 17 Sep	Scandinavian Airlines
29 Sep - 07 Oct	Spirit Airlines
04 Sep - 18 Sep	Scandinavian Airlines
07 Sep - 14 Sep	Icelandair
03 Sep - 10 Sep	United
05 Sep - 12 Sep	United
30 Sep - 31 Oct	United
28 Sep - 05 Oct	United
25 Sep - 02 Oct	United

Also check the deals for one-way flights from Chicago to Prague in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Chicago to Prague in September from $454

Return flights