Cheapest return flights from Chicago to Panama City in October from $266

AirHint found the following cheapest return flights from Chicago (ORD) to Panama City (PTY) in October 2025 (see full year).

Return flights

23 Oct - 27 Oct Avianca
23 Oct - 30 Oct Avianca
03 Oct - 06 Oct Spirit Airlines
05 Oct - 09 Oct Spirit Airlines
10 Oct - 18 Oct Spirit Airlines
25 Oct - 02 Nov Spirit Airlines
10 Oct - 10 Nov Avianca
17 Oct - 21 Oct Avianca
03 Oct - 06 Oct Copa direct
10 Oct - 18 Oct Copa direct
23 Oct - 30 Oct Copa direct
02 Oct - 05 Oct Copa direct
10 Oct - 10 Nov Copa direct
25 Oct - 02 Nov Copa direct

Also check the deals for one-way flights from Chicago to Panama City in October.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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