AirHint found the following cheapest return flights from Chicago (ORD) to Panama City (PTY) in May 2026 (see full year).

Return flights

20 May - 27 May	Spirit Airlines
30 May - 01 Jun	Spirit Airlines
08 May - 13 May	Spirit Airlines
30 May - 06 Jun	Spirit Airlines
01 May - 10 May	Spirit Airlines
20 May - 27 May	Copa	direct
01 May - 10 May	Copa	direct
08 May - 13 May	Copa	direct
30 May - 01 Jun	Copa	direct
30 May - 06 Jun	Copa	direct

Also check the deals for one-way flights from Chicago to Panama City in May.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Chicago to Panama City in May from $403

Return flights