AirHint found the following cheapest return flights from Orlando (ORL) to Panama City (PTY) in September 2025 (see full year).

Return flights

05 Sep - 09 Sep	Spirit Airlines
01 Sep - 08 Sep	Spirit Airlines
01 Sep - 08 Sep	Copa	direct
08 Sep - 15 Sep	Copa	direct
05 Sep - 14 Sep	Copa	direct
18 Sep - 28 Sep	Copa	direct
05 Sep - 09 Sep	Copa	direct
11 Sep - 14 Sep	Copa	direct
15 Sep - 18 Sep	Copa	direct

Also check the deals for one-way flights from Orlando to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Orlando to Panama City in September from $348

Return flights