AirHint found the following cheapest return flights from Prestwick (PIK) to Prague (PRG) in December 2025 (see full year).

Return flights

13 Dec - 15 Dec	Ryanair
12 Dec - 15 Dec	Ryanair
18 Dec - 23 Dec	Ryanair
15 Dec - 17 Dec	Ryanair
15 Dec - 19 Dec	Ryanair
29 Dec - 02 Jan	Ryanair
14 Dec - 18 Dec	Ryanair
20 Dec - 27 Dec	Ryanair
06 Dec - 20 Dec	Ryanair
30 Dec - 01 Jan	Ryanair
30 Dec - 04 Jan	Ryanair
28 Dec - 02 Jan	Ryanair
30 Dec - 02 Jan	Ryanair
28 Dec - 01 Jan	Ryanair

Also check the deals for one-way flights from Prestwick to Prague in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Prestwick to Prague in December from $293

Return flights