AirHint found the following cheapest return flights from Palermo (PMO) to Istanbul (IST) in October 2025 (see full year).

Return flights

22 Oct - 31 Oct	Aeroitalia
22 Oct - 29 Oct	Ryanair
22 Oct - 28 Oct	Ryanair
23 Oct - 29 Oct	easyJet
08 Oct - 14 Oct	easyJet
25 Oct - 30 Oct	Turkish Airlines
28 Oct - 31 Oct	Aeroitalia
08 Oct - 15 Oct	Ryanair
22 Oct - 27 Oct	Ryanair
28 Oct - 01 Nov	Ryanair
07 Oct - 13 Oct	easyJet
28 Oct - 04 Nov	Ryanair
31 Oct - 02 Nov	Aeroitalia
25 Oct - 02 Nov	Aeroitalia
29 Oct - 02 Nov	Aeroitalia
27 Oct - 03 Nov	Ryanair
25 Oct - 02 Nov	Turkish Airlines	direct
31 Oct - 02 Nov	Turkish Airlines	direct

Also check the deals for one-way flights from Palermo to Istanbul in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Palermo to Istanbul in October from $194

Return flights