AirHint found the following cheapest return flights from Palermo (PMO) to Istanbul (IST) in October 2025 (see full year).

Return flights

16 Oct - 21 Oct	Ryanair
23 Oct - 26 Oct	Volotea
15 Oct - 19 Oct	Ryanair
20 Oct - 22 Oct	Volotea
20 Oct - 25 Oct	Volotea
13 Oct - 19 Oct	Ryanair
16 Oct - 22 Oct	easyJet
09 Oct - 11 Oct	easyJet
22 Oct - 27 Oct	Aeroitalia
06 Oct - 09 Oct	Aeroitalia
31 Oct - 09 Nov	Volotea
31 Oct - 02 Nov	Volotea
31 Oct - 03 Nov	Volotea
25 Oct - 02 Nov	Turkish Airlines
25 Oct - 02 Nov	Turkish Airlines	direct
26 Oct - 02 Nov	Ryanair
26 Oct - 02 Nov	Turkish Airlines	direct
31 Oct - 09 Nov	Turkish Airlines	direct
31 Oct - 03 Nov	Turkish Airlines	direct

Also check the deals for one-way flights from Palermo to Istanbul in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Palermo to Istanbul in October from $182

Return flights