AirHint found the following cheapest return flights from Palermo (PMO) to Istanbul (IST) in December 2025 (see full year).

Return flights

16 Dec - 21 Dec	Aeroitalia
10 Dec - 12 Dec	Ryanair
03 Dec - 06 Dec	Ryanair
12 Dec - 14 Dec	Ryanair
12 Dec - 15 Dec	Ryanair
15 Dec - 19 Dec	Ryanair
08 Dec - 15 Dec	Ryanair
13 Dec - 15 Dec	Ryanair
11 Dec - 13 Dec	Lufthansa
12 Dec - 21 Dec	Ryanair
16 Dec - 13 Jan	Ryanair
24 Dec - 02 Jan	Ryanair
17 Dec - 14 Jan	Turkish Airlines	direct
31 Dec - 09 Jan	Turkish Airlines
31 Dec - 09 Jan	Turkish Airlines	direct
29 Dec - 04 Jan	Ryanair
30 Dec - 04 Jan	Ryanair
31 Dec - 04 Jan	Turkish Airlines
31 Dec - 05 Jan	Turkish Airlines
27 Dec - 01 Jan	Ryanair

Also check the deals for one-way flights from Palermo to Istanbul in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Palermo to Istanbul in December from $187

Return flights