AirHint found the following cheapest return flights from Palermo (PMO) to Prague (PRG) in October 2025 (see full year).

Return flights

24 Oct - 28 Oct	easyJet
21 Oct - 28 Oct	easyJet
21 Oct - 25 Oct	easyJet
20 Oct - 25 Oct	easyJet
06 Oct - 11 Oct	Ryanair
01 Oct - 07 Oct	easyJet
08 Oct - 11 Oct	easyJet
17 Oct - 22 Oct	easyJet
09 Oct - 15 Oct	Ryanair
10 Oct - 14 Oct	Ryanair
29 Oct - 04 Nov	easyJet
27 Oct - 02 Nov	Ryanair
29 Oct - 03 Nov	easyJet
26 Oct - 02 Nov	Ryanair
30 Oct - 02 Nov	easyJet
28 Oct - 01 Nov	easyJet

Also check the deals for one-way flights from Palermo to Prague in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Palermo to Prague in October from $131

Return flights