AirHint found the following cheapest return flights from Palermo (PMO) to Prague (PRG) in October 2025 (see full year).

Return flights

24 Oct - 29 Oct	easyJet
25 Oct - 08 Nov	easyJet
16 Oct - 20 Oct	easyJet
24 Oct - 08 Nov	easyJet
24 Oct - 26 Oct	easyJet
24 Oct - 07 Nov	easyJet
10 Oct - 13 Oct	easyJet
04 Oct - 07 Oct	easyJet
24 Oct - 01 Nov	easyJet
28 Oct - 11 Nov	easyJet
29 Oct - 12 Nov	easyJet
31 Oct - 08 Nov	easyJet
24 Oct - 28 Oct	easyJet
04 Oct - 08 Oct	easyJet
16 Oct - 19 Oct	easyJet
31 Oct - 15 Nov	easyJet
19 Oct - 12 Nov	easyJet
27 Oct - 10 Nov	Ryanair
04 Oct - 20 Oct	Vueling Airlines
04 Oct - 19 Oct	Vueling Airlines

Also check the deals for one-way flights from Palermo to Prague in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Palermo to Prague in October from $127

Return flights