AirHint found the following cheapest return flights from Palermo (PMO) to Prague (PRG) in September 2025 (see full year).

Return flights

24 Sep - 30 Sep	Ryanair
24 Sep - 28 Sep	Aeroitalia
15 Sep - 24 Sep	Ryanair
24 Sep - 27 Sep	Ryanair
25 Sep - 29 Sep	Ryanair
25 Sep - 01 Oct	Aeroitalia
17 Sep - 22 Sep	Ryanair
27 Sep - 01 Oct	Ryanair
06 Sep - 13 Sep	Ryanair
27 Sep - 04 Oct	Ryanair
18 Sep - 25 Sep	Ryanair
18 Sep - 21 Sep	Ryanair
27 Sep - 30 Sep	Ryanair
30 Sep - 04 Oct	Ryanair
26 Sep - 04 Oct	Ryanair
30 Sep - 12 Oct	Vueling Airlines
23 Sep - 12 Oct	Vueling Airlines
25 Sep - 12 Oct	Vueling Airlines
30 Sep - 20 Oct	Vueling Airlines
30 Sep - 13 Oct	Vueling Airlines

Also check the deals for one-way flights from Palermo to Prague in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Palermo to Prague in September from $164

Return flights