AirHint found the following cheapest return flights from Prague (PRG) to Cape Town (CPT) in September 2025 (see full year).

Return flights

23 Sep - 14 Oct	Condor
08 Sep - 14 Sep	Wizz Air Malta
20 Sep - 05 Oct	Condor
01 Sep - 14 Sep	Wizz Air Malta
09 Sep - 16 Sep	Norwegian Air Sweden AOC
01 Sep - 25 Sep	KLM
08 Sep - 15 Sep	KLM
11 Sep - 18 Sep	KLM
10 Sep - 17 Sep	KLM
01 Sep - 02 Oct	KLM
19 Sep - 09 Oct	KLM
19 Sep - 05 Oct	KLM
02 Sep - 12 Sep	Turkish Airlines

Also check the deals for one-way flights from Prague to Cape Town in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Prague to Cape Town in September from $783

Return flights