AirHint found the following cheapest return flights from Prague (PRG) to Panama City (PTY) in October 2025 (see full year).

Return flights

12 Oct - 20 Oct	Condor
29 Oct - 13 Nov	Condor
26 Oct - 10 Nov	Condor
29 Oct - 10 Nov	Condor
08 Oct - 13 Oct	Condor
08 Oct - 20 Oct	Condor
01 Oct - 13 Oct	Condor
01 Oct - 20 Oct	Condor
05 Oct - 13 Oct	Condor
29 Oct - 03 Nov	Condor
26 Oct - 03 Nov	Condor
01 Oct - 06 Oct	Condor
01 Oct - 09 Oct	Condor
22 Oct - 27 Oct	Condor
05 Oct - 14 Oct	Wizz Air UK
31 Oct - 14 Nov	Ryanair
22 Oct - 01 Nov	Turkish Airlines

Also check the deals for one-way flights from Prague to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Prague to Panama City in October from $513

Return flights