AirHint found the following cheapest return flights from Panama City (PTY) to Rome (FCO) in October 2025 (see full year).

Return flights

13 Oct - 22 Oct	Condor
05 Oct - 14 Oct	Turkish Airlines
15 Oct - 22 Oct	Turkish Airlines
03 Oct - 15 Oct	Turkish Airlines
29 Oct - 07 Nov	KLM
07 Oct - 14 Oct	Turkish Airlines
09 Oct - 20 Oct	Avianca
31 Oct - 16 Nov	Avianca
29 Oct - 09 Nov	Turkish Airlines
29 Oct - 08 Nov	Turkish Airlines
04 Oct - 16 Oct	Air Europa

Also check the deals for one-way flights from Panama City to Rome in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Rome in October from $529

Return flights