AirHint found the following cheapest return flights from Panama City (PTY) to Guatemala City (GUA) in October 2025 (see full year).

Return flights

13 Oct - 30 Oct	Avianca
27 Oct - 03 Nov	Avianca
01 Oct - 05 Oct	Avianca
03 Oct - 06 Oct	Avianca
02 Oct - 05 Oct	Avianca
03 Oct - 10 Oct	Avianca
04 Oct - 06 Oct	Avianca
16 Oct - 20 Oct	Avianca
31 Oct - 03 Nov	Copa
30 Oct - 06 Nov	Avianca
02 Oct - 09 Oct	Copa
01 Oct - 05 Oct	Copa	direct
10 Oct - 13 Oct	Copa	direct
30 Oct - 06 Nov	Copa	direct
31 Oct - 09 Nov	Copa
31 Oct - 05 Nov	Copa
31 Oct - 06 Nov	Copa

Also check the deals for one-way flights from Panama City to Guatemala City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Guatemala City in October from $255

Return flights