AirHint found the following cheapest return flights from Panama City (PTY) to Guatemala City (GUA) in November 2025 (see full year).

Return flights

08 Nov - 08 Dec	Avianca
08 Nov - 07 Dec	Avianca
28 Nov - 30 Nov	Avianca
01 Nov - 09 Nov	Avianca
01 Nov - 15 Nov	Avianca
09 Nov - 07 Dec	Copa
30 Nov - 04 Dec	Copa	direct
09 Nov - 15 Nov	Copa
17 Nov - 21 Nov	Copa
17 Nov - 19 Nov	Copa
01 Nov - 10 Nov	Copa
01 Nov - 03 Nov	Copa
21 Nov - 24 Nov	Copa
27 Nov - 30 Nov	Copa	direct

Also check the deals for one-way flights from Panama City to Guatemala City in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Guatemala City in November from $307

Return flights