AirHint found the following cheapest return flights from Panama City (PTY) to Istanbul (IST) in October 2025 (see full year).

Return flights

27 Oct - 05 Nov	Air Europa
20 Oct - 31 Oct	Air Europa
21 Oct - 01 Nov	Air Europa
28 Oct - 10 Nov	Air Europa
17 Oct - 24 Oct	Air Europa
09 Oct - 20 Oct	Copa
13 Oct - 29 Oct	Avianca
08 Oct - 19 Oct	Copa
10 Oct - 17 Oct	Avianca
08 Oct - 12 Oct	Avianca
09 Oct - 13 Oct	Avianca
27 Oct - 09 Nov	Air Europa
17 Oct - 27 Oct	Copa
31 Oct - 10 Nov	Copa
30 Oct - 09 Nov	Air Europa
08 Oct - 19 Oct	Copa	direct
21 Oct - 01 Nov	Turkish Airlines	direct
28 Oct - 10 Nov	Turkish Airlines	direct
27 Oct - 05 Nov	Turkish Airlines	direct
31 Oct - 10 Nov	Turkish Airlines	direct

Also check the deals for one-way flights from Panama City to Istanbul in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Istanbul in October from $828

Return flights