AirHint found the following cheapest return flights from Panama City (PTY) to Istanbul (IST) in May 2026 (see full year).

Return flights

10 May - 20 May	KLM
09 May - 07 Jun	KLM
19 May - 01 Jun	KLM
29 May - 08 Jun	Air Europa
16 May - 30 May	KLM
04 May - 15 May	Air Europa
18 May - 31 May	Air Europa
05 May - 16 May	Air Europa
18 May - 30 May	Air Europa
09 May - 17 May	Avianca
05 May - 16 May	Turkish Airlines	direct
16 May - 30 May	Turkish Airlines	direct
29 May - 08 Jun	Turkish Airlines	direct

Also check the deals for one-way flights from Panama City to Istanbul in May.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Istanbul in May from $956

Return flights