AirHint found the following cheapest return flights from Panama City (PTY) to Rio Negro (MDE) in October 2025 (see full year).

Return flights

04 Oct - 08 Oct	Wingo	direct
03 Oct - 10 Oct	Wingo	direct
24 Oct - 27 Oct	Wingo	direct
03 Oct - 07 Oct	Wingo	direct
17 Oct - 19 Oct	Wingo	direct
10 Oct - 13 Oct	Wingo	direct
06 Oct - 10 Oct	Wingo	direct
16 Oct - 21 Oct	Wingo	direct
23 Oct - 26 Oct	Wingo	direct
15 Oct - 22 Oct	Wingo	direct
09 Oct - 03 Nov	Wingo	direct
26 Oct - 05 Nov	Wingo	direct
31 Oct - 09 Nov	Wingo	direct
30 Oct - 06 Nov	Wingo	direct
31 Oct - 07 Nov	Wingo	direct
30 Oct - 07 Nov	Copa	direct
31 Oct - 05 Nov	Wingo	direct
31 Oct - 06 Nov	Avianca
31 Oct - 06 Nov	Copa	direct

Also check the deals for one-way flights from Panama City to Rio Negro in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Rio Negro

Cheap car rent in Rio Negro

Cheapest return flights from Panama City to Rio Negro in October from $148

Return flights