AirHint found the following cheapest return flights from Panama City (PTY) to Rio Negro (MDE) in December 2025 (see full year).

Return flights

11 Dec - 18 Dec	Wingo	direct
25 Dec - 09 Jan	Wingo	direct
02 Dec - 04 Dec	Wingo	direct
17 Dec - 24 Dec	Wingo	direct
18 Dec - 23 Dec	Wingo	direct
17 Dec - 22 Dec	Wingo	direct
21 Dec - 11 Jan	Wingo	direct
14 Dec - 21 Dec	Wingo	direct
27 Dec - 03 Jan	Wingo	direct
27 Dec - 31 Dec	Wingo	direct
14 Dec - 24 Dec	Wingo	direct
23 Dec - 03 Jan	Wingo	direct
01 Dec - 05 Dec	Copa	direct
24 Dec - 01 Jan	Wingo	direct
23 Dec - 27 Dec	Wingo	direct
24 Dec - 17 Jan	Copa	direct
14 Dec - 05 Jan	Wingo	direct
17 Dec - 06 Jan	Copa	direct
28 Dec - 02 Jan	Wingo	direct
22 Dec - 06 Jan	Copa	direct

Also check the deals for one-way flights from Panama City to Rio Negro in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Rio Negro

Cheap car rent in Rio Negro

Cheapest return flights from Panama City to Rio Negro in December from $204

Return flights