AirHint found the following cheapest return flights from Panama City (PTY) to Mexico City (MEX) in October 2025 (see full year).

Return flights

31 Oct - 08 Nov	Avianca
06 Oct - 09 Oct	Avianca
01 Oct - 15 Oct	Avianca
06 Oct - 10 Oct	Avianca
01 Oct - 15 Oct	Aeromexico	direct
08 Oct - 12 Oct	Aeromexico	direct
10 Oct - 15 Oct	Copa	direct
22 Oct - 27 Oct	Copa	direct
17 Oct - 10 Nov	Avianca
31 Oct - 05 Nov	Avianca
29 Oct - 03 Nov	Avianca
31 Oct - 09 Nov	Avianca
31 Oct - 07 Nov	Avianca
25 Oct - 10 Nov	Copa	direct
24 Oct - 10 Nov	Copa	direct
31 Oct - 09 Nov	Copa	direct
06 Oct - 09 Oct	Copa	direct
06 Oct - 10 Oct	Copa	direct
17 Oct - 10 Nov	Copa	direct

Also check the deals for one-way flights from Panama City to Mexico City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Mexico City in October from $325

Return flights