AirHint found the following cheapest return flights from Panama City (PTY) to Mexico City (MEX) in December 2025 (see full year).

Return flights

26 Dec - 02 Jan	Copa	direct
19 Dec - 27 Dec	Avianca
08 Dec - 20 Dec	Avianca
05 Dec - 14 Dec	Avianca
05 Dec - 14 Dec	Aeromexico	direct
06 Dec - 13 Dec	Copa	direct
11 Dec - 14 Dec	Avianca
19 Dec - 04 Jan	Aeromexico	direct
03 Dec - 08 Dec	Copa	direct
11 Dec - 14 Dec	Copa	direct
20 Dec - 16 Jan	Copa	direct
27 Dec - 10 Jan	Avianca
27 Dec - 10 Jan	Copa	direct
08 Dec - 20 Dec	Copa	direct
19 Dec - 27 Dec	Copa	direct

Also check the deals for one-way flights from Panama City to Mexico City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Mexico City in December from $279

Return flights