AirHint found the following cheapest return flights from Panama City (PTY) to Mexico City (MEX) in December 2025 (see full year).

Return flights

25 Dec - 31 Dec	Aeromexico	direct
24 Dec - 31 Dec	Aeromexico	direct
24 Dec - 30 Dec	Aeromexico	direct
24 Dec - 01 Jan	Aeromexico	direct
25 Dec - 01 Jan	Aeromexico	direct
31 Dec - 09 Jan	Copa	direct
21 Dec - 31 Dec	Aeromexico	direct
17 Dec - 31 Dec	Aeromexico	direct
05 Dec - 11 Dec	Copa	direct
06 Dec - 13 Dec	Copa	direct
29 Dec - 09 Jan	Copa	direct
27 Dec - 06 Jan	Copa	direct
27 Dec - 03 Jan	Copa	direct
28 Dec - 05 Jan	Copa	direct
26 Dec - 28 Jan	Copa	direct
28 Dec - 04 Jan	Copa	direct
27 Dec - 04 Jan	Aeromexico	direct
05 Dec - 08 Dec	Copa	direct
03 Dec - 06 Dec	Copa	direct
06 Dec - 09 Dec	Avianca

Also check the deals for one-way flights from Panama City to Mexico City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Mexico City in December from $270

Return flights